• Feedback
  • RSS Feed
  • Sitemap
Ommcom News
  • Home
  • Odisha
  • Nation
  • World
  • Sports
  • Business
  • Entertainment
  • Videos
  • Science & Tech
  • Photo Gallery
  • ଓଡ଼ିଆରେ ପଢନ୍ତୁ
No Result
View All Result
  • Home
  • Odisha
  • Nation
  • World
  • Sports
  • Business
  • Entertainment
  • Videos
  • Science & Tech
  • Photo Gallery
  • ଓଡ଼ିଆରେ ପଢନ୍ତୁ
No Result
View All Result
Odisha News, Odisha Breaking News, Odisha Latest News || Ommcom News
Home Science & Tech

New Covid-19 Drugs May Develop By Targeting Coronavirus Ion Channel: Study

OMMCOM NEWS by OMMCOM NEWS
October 14, 2023
in Science & Tech

San Francisco: Researchers have discovered the structures of open and closed states of the coronavirus ion channel, which could help the development of antiviral drugs to reduce inflammation, a new study has said.

According to the study published in the journal Science Advances, the genome of the SARS-CoV-2 virus encodes 29 proteins, one of which is an ion channel called ‘E’, which transports protons and calcium ions, induces infected cells to launch an inflammatory response that damages tissues and contributes to the symptoms of Covid-19.

“The E channel is an antiviral drug target. If you can stop the channel from sending calcium into the cytoplasm, then you have a way to reduce the cytotoxic effects of the virus,” said Mei Hong, senior author of the study and a chemistry professor at the Massachusetts Institute of Technology (MIT).

When SARS-CoV-2 infects cells, the E channel embeds itself inside the membrane that surrounds a cellular organelle called the ER-Golgi intermediate compartment (ERGIC).

The ERGIC interior has a high concentration of protons and calcium ions, which the E channel transports out of ERGIC and into the cell cytoplasm.

To study membrane-embedded proteins such as ion channels, the researchers have developed techniques that use nuclear magnetic resonance (NMR) spectroscopy to reveal the atomic-level structures of those proteins.

“By 2020, we had matured all the NMR technologies to solve the structure of this kind of alpha-helical bundles in the membrane, so we were able to solve the closed E structure in about six months,” Hong said.

Hong is presently creating compounds with researchers at the University of California, US, that can bind to the E channel and prevent ions from passing through it, in the hopes of developing antiviral medications that can lessen the inflammation caused by SARS-CoV-2.

She is also planning to investigate how mutations in subsequent variants of SARS-CoV-2 might affect the structure and function of the E channel.

“The E variant in Omicron is something we want to study next. We can make a mutant and see how disruption of that polar network changes the structural and dynamical aspect of this protein,” Hong stated.

(IANS)

ShareTweetSendSharePinShareSend
Previous Post

Coast Guard Evacuates Critically Ill Chinese Crewman From Ship In Arabian Sea

Next Post

On Suspicion Of Honey Trapping, K’taka Woman Paraded With Garland Of Shoes

Related Posts

Science & Tech

India To Host Global Research Symposium On AI And Its Impact In Feb 2026

October 7, 2025
Science & Tech

WHO Issues New Guidelines To Tackle Deaths From Excessive Bleeding After Childbirth

October 6, 2025
Sridhar Vembu
Odisha

Zoho To Set Up Data Centre In Odisha: Founder Sridhar Vembu

October 2, 2025
Science & Tech

Poor Air Quality May Worsen Sleep Apnoea: Study

September 29, 2025
BSNL 4G
Business

BSNL‘S Indigenous 4G Stack Powers India’s Swadeshi Drive

September 28, 2025
Heart
Science & Tech

Heart Diseases Kill 8 People Every Minute In South-East Asia: WHO

September 27, 2025
Next Post

On Suspicion Of Honey Trapping, K'taka Woman Paraded With Garland Of Shoes

PM To Inaugurate 141st IOC Session Today In Mumbai

Protest Against Rajasthan Minister Zahida Khan At Congress Hqrs Alleging Harassment, Corruption

Khimji
OMC
  • Feedback
  • RSS Feed
  • Sitemap

© 2025 - Ommcom News. All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In

Add New Playlist

No Result
View All Result
  • Home
  • Odisha
  • Nation
  • World
  • Sports
  • Business
  • Entertainment
  • Videos
  • Science & Tech
  • Photo Gallery
  • ଓଡ଼ିଆରେ ପଢନ୍ତୁ

© 2025 - Ommcom News. All Rights Reserved.